Foxconn Int'l says unaware of any reason for stock jump

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Source: http://news.yahoo.com/foxconn-intl-says-unaware-reason-stock-jump-023450505--finance.html

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Niger: Floods kill 91 people, says official

NIAMEY, Niger (AP) ? A top official in Niger said the country's recent floods have killed 91 people and caused significant damage.

The director of the cabinet, Aghaly Abdoulkader, said all eight regions of the country are affected by the floods, including the large regions of Tillabery, Dosso and Niamey. The floods have damaged fields, rice paddies, water points, schools, health centers, roads, bridges and dams, he said. In addition large quantities of food have been destroyed and many cattle have washed away.

Twelve irrigation schemes in the Niger River valley, totaling 3,050 hectares (7,536 acres) were completely flooded after a major river surge recently.

Source: http://news.yahoo.com/niger-floods-kill-91-people-says-official-135424297.html

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Sprint LG Mach specs

• Android 4.0, Ice Cream Sandwich
• Dimensions: 4.64" (H) x 2.56" (W) x 0.48" (D)
• Weight: 5.92 oz
• Full QWERTY slide out keyboard
• 1.2GHz dual-core processor
• Qualcomm MSM8960 chipset
• 1GB RAM
• 4” WVGA touch screen (480 x 800)
• 8GB eMMC and microSD card slot (up to 32GB)
• Battery: 1700mAh Li-ion
• Personal and business email and text messaging, as well as IM through Google Talk™
• Google Mobile™ wireless services such as Google Search™, Gmail™, Google
• Maps™ for Android, Google Calendar™, Voice Search and YouTube™
• 3G/4G LTE Mobile Hotspot capability supporting up to eight Wi-Fi enabled devices simultaneously
• Wi-Fi® 802.11 b/g/n
• Dual Cameras: 5-megapixel rear-facing with flash and video capture and 0.3 megapixel VGA front-facing camera
• 1080p HD recording, uploading and playback
• LG QuickMemo gives users the ability to personalize messages and share comments across a wide range of content including web pages, digital magazines, photos and more – all with a simple swipe of your finger
• Time Catch Shot™ allows users to take up to 5 images based on image resolution. Users can review the thumbnail images to choose the best shot
• Play Store with more than 600,000 apps, millions of songs and books and thousands of movies Play Store has something for everyone
• Sprint ID offering an innovative way to personalize an Android smartphone with apps, widgets, ringtones and more all in a single download
• 3.5mm stereo headset jack
• Bluetooth® 4.0

Source: http://feedproxy.google.com/~r/androidcentral/~3/-hTpOyYcFDM/story01.htm

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U.S. picks retired diplomat to serve as envoy in Libya

WASHINGTON (Reuters) - The United States has chosen a veteran diplomat who retired more than a decade ago to serve as its senior envoy in Libya following the death of Ambassador Christopher Stevens in a September 11 attack in Benghazi, the State Department said on Thursday.

Laurence Pope, a former U.S. ambassador to Chad and senior State Department counter-terrorism official, has arrived in Tripoli to serve as "charge d'affairs," the title given to a diplomat who represents a country in the absence of an ambassador, State Department spokeswoman Victoria Nuland said in a statement.

"Mr. Pope's selection as charge d'affairs emphasizes the commitment of the United States to the relationship between our two countries and to the people of Libya as they move forward in their transition to a democratic government," Nuland said.

"We will continue to assist as Libya builds democratic institutions and broad respect for the rule of law - the goals that Ambassador Stevens worked hard to achieve," she added.

Stevens and three other Americans were killed during what the United States has called a "terrorist" attack on the American mission in Benghazi on September 11.

The incident has triggered a debate in Washington over whether the ambassador, and the U.S. mission in Benghazi more broadly, were given sufficient protection.

At a partisan and at times rancorous congressional hearing on Wednesday on events leading to the death of Stevens, security officers described uphill bureaucratic battles for resources to protect U.S. personnel and facilities.

The assault forced the evacuation of U.S. personnel from Benghazi, the eastern city that was the hub for the Libyan rebel movement that, with the assistance of NATO-led air strikes, toppled former Libyan dictator Muammar Gaddafi last year.

Pope's 31-year career as a foreign service officer, which ended with his retirement in 2000, included stints as political adviser to the commander of the U.S. military's Central Command, which covers much of the Middle East, and as the State Department's director for Northern Gulf Affairs. He speaks Arabic and French.

(Reporting By Arshad Mohammed; Editing by Will Dunham)

Source: http://news.yahoo.com/u-picks-retired-diplomat-serve-envoy-libya-213635186.html

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New studies could result in better treatments for epilepsy, behavioral disorders

ScienceDaily (Oct. 11, 2012) ? Three studies conducted as part of Wayne State University's Systems Biology of Epilepsy Project (SBEP) could result in new types of treatment for the disease and, as a bonus, for behavioral disorders as well.

The SBEP started out with funds from the President's Research Enhancement Fund and spanned neurology, neuroscience, genetics and computational biology. It since has been supported by multiple National Institutes of Health-funded grants aimed at identifying the underlying causes of epilepsy, and it is uniquely integrated within the Comprehensive Epilepsy Program at the Wayne State School of Medicine and the Detroit Medical Center.

Under the guidance of Jeffrey Loeb, M.D., Ph.D., associate director of the Center for Molecular Medicine and Genetics (CMMG) and professor of neurology, the project brings together researchers from different fields to create an interdisciplinary research program that targets the complex disease. The multifaceted program at Wayne State is like no other in the world, officials say, with two primary goals: improving clinical care and creating novel strategies for diagnosis and treatment of patients with epilepsy.

The three studies were published in high-impact journals and use human brain tissue research to identify new targets for drug development, generate a new animal model and identify a new class of drugs to treat the disease. In the first study, "Layer-Specific CREB Target Gene Induction in Human Neocortical Epilepsy," published recently in the Journal of Neuroscience, donated human brain samples were probed to identify 137 genes strongly associated with epileptic seizures.

Researchers then showed that the most common pathway is activated in very specific layers of the cortex, and that it's associated with increased numbers of synapses in those areas. Because epilepsy is a disease of abnormal neuronal synchrony, the finding could explain why some brain regions produce clinical seizures.

"Higher density of synapses may explain how abnormal epileptic discharges, or spikes, are formed, and in what layer," Loeb said, adding that localizing the exact layer of the brain in which that process occurs is useful both for understanding the mechanism and for developing therapeutics.

The first study, which identified a new drug target for epilepsy, precipitated a second study that has found such a drug.

In the second study, "Electrical, Molecular and Behavioral Effects of Interictal Spiking in the Rat," published recently in Neurobiology of Disease, SBEP researchers found that the same brain layers in the rat are activated as in the human tissues and searched for a drug to target those layers. In fact, the first drug they tried, a compound called SL327 that has been used in nonhuman subjects to understand how memory works, "worked like a dream," Loeb said. "SL327 prevented spiking in rat brains," he said, "which not only prevented seizures, but led to more normal behaviors as well."

That finding led to collaborations between Loeb's lab and Nash Boutros, M.D., professor of psychiatry and behavioral neurosciences, and the Belgian drug company UCB.

"Whereas animals that developed epileptic spiking became hyperactive, those treated with the drug and had less spiking in their brains were more like normal animals," Loeb said. "Now whenever we screen for drugs for epilepsy, we look at behavior as well as epileptic activity."

Noting that many seizure medicines currently are used to treat various psychiatric disorders, Loeb said the SBEP team's latest round of work marks a "nice crossover" between psychiatry and neurology in the field of drugs related to epilepsy.

In the third study, just published in Genetics, researchers say they have found "fascinating interrelationships" between "junk" long noncoding RNA and normal RNA that are regulated by human brain activity. That work has the potential to be translated into new genetic treatments for epilepsy.

"This study shows how the human brain deals with half of the human genome in its most important function, electrical activity, using human brain tissue from patients with epilepsy to understand the basic molecular processes of how the brain works, and what's unique about human brains compared to the brains of less-developed species," Loeb said.

The third study, titled "Activity-Dependent Human Brain Coding/Noncoding Gene Regulatory Networks," is a collaborative effort between Loeb's lab and Leonard Lipovich, Ph.D., assistant professor of neurology and molecular medicine and genetics. It found that certain genes and their noncoding counterparts (which some researchers have called "junk") are co-regulated, or turned on at the same time, with brain activity.

"This tells us that some of these noncoding genes may actually have functions in brain activity," Loeb said. "In some, turning one on turns another one off. Some are regulatory and can be used to control plasticity genes -- which are involved in memory, learning and behavior -- with one of these novel, noncoding RNA genes."

The synergy exhibited by the three studies, Loeb said, is testimony to the multidisciplinary nature of Wayne State's systems biology platform, partly developed with a remarkable three-dimensional database created in cooperation with Farshad Fotouhi, Ph.D., dean of the College of Engineering, and Jing Hua, Ph.D., associate professor of computer science.

"SBEP is a cross-campus endeavor," Loeb said. "These studies are the fruits of the labor of this consortium and only exist at WSU. The next steps will be translating these exciting findings into new treatments to prevent or even cure patients with epilepsy and other psychiatric disorders."

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Story Source:

The above story is reprinted from materials provided by Wayne State University - Office of the Vice President for Research, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal References:

1. Thomas L. Beaumont, Bin Yao, Aashit Shah, Gregory Kapatos and Jeffrey A. Loeb. Layer-Specific CREB Target Gene Induction in Human Neocortical Epilepsy. Journal of Neuroscience, 2012 DOI: 10.1523/%u200BJNEUROSCI.3408-12.2012
2. Daniel T. Barkmeier, Danielle Senador, Karine Leclercq, Darshan Pai, Jing Hua, Nash N. Boutros, Rafal M. Kaminski, Jeffrey A. Loeb. Electrical, molecular and behavioral effects of interictal spiking in the rat. Neurobiology of Disease, 2012; 47 (1): 92 DOI: 10.1016/j.nbd.2012.03.026
3. L. Lipovich, F. Dachet, J. Cai, S. Bagla, K. Balan, H. Jia, J. A. Loeb. Activity-dependent Human Brain Coding/Non-coding Gene Regulatory Networks. Genetics, 2012; DOI: 10.1534/genetics.112.145128

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/IyZ_kYgiFAc/121011162156.htm

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Facebook to ask your OK before sharing actions

11 hrs.

Suzanne Choney , NBC News

Tired of Facebook sharing every little article you read or song you?listen to, using its "Open Graph" system? So is Facebook, apparently.?Apps will soon need user permission to share "like," "follow," "listen," "read" or "watch" actions, according to product engineer Henry Zhang, who posted the new rules on?Facebook's developer blog.

"In order to provide users with experiences that meet their expectations, we will no longer approve custom actions that publish stories as people consume content," he wrote. "These apps must use the appropriate?built-in actions?or create a different sharing experience."

"Apps that help people automatically share stories about content as they consume it, such as the music you are listening to, can be good experiences when apps create clear expectations for the user of what is being shared and when," Zhang wrote. "When apps automatically publish stories on a person?s behalf in a way that is unexpected, such as when they browse an online store, it can surprise and confuse people."

The change is to take place "in the next 90 days," Zhang said.

Meanwhile, Facebook stories that lead with images and location are being made "more prominent" in Facebook's news feeds and Timeline, Zhang said.

"In early tests, the new image-led stories have shown 70 percent more clicks for apps that provide high quality, relevant imagery with low spam rates," Zhang wrote. "In certain cases, we have seen these stories generate up to 50x more Likes than equivalent story types from before. The new location stories provide double-digit gains in distribution to apps."

The Open Graph?changes may be welcome, but they're not totally altruistic: Facebook will annoy fewer of its users, but its goal is probably to be better "liked" by the Federal Trade Commission. The agency?recently settled charges with Facebook over deceiving consumers and making them share more personal info they they intended.

The settlement requires Facebook to get user consent for?some changes to privacy settings, and also subjects the site to 20 years of independent audits.

Check out Technolog, Gadgetbox, Digital Life and In-Game on?Facebook,?and on?Twitter, follow Suzanne Choney.

Source: http://www.nbcnews.com/technology/technolog/facebook-ask-your-permission-sharing-your-actions-1C6412194

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Ethan Hawke Gets Sinister - Interview

by Grae Drake | Wednesday, Oct. 10 2012 2 comments Ethan Hawke ditches his sensitive-guy persona in favor of straight-up horror in Sinister. He talks to Grae Drake about why he made a scary movie and what images from the movie he had a hard time shaking when the cameras stopped rolling.

Source: http://www.rottentomatoes.com/m/1926022/news/1926022/

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